Comparision of Astrazeneca (British) and Sinovac (Chinese) Vaccine against COVID-19
The number of vaccines used to fight the COVID-19 epidemic is constantly growing, with many international candidates entering the US market.
Oxford University and AstraZeneca have teamed up in the UK to create a recombinant vaccine made from a modified chimpanzee virus. Another candidate is from Sinovac Biotech in China. Sinovac uses a more traditional vaccination technology to generate an immune response based on inactivated viral particles.
None of these vaccines have been approved for routine or emergency use in the United States. A number of studies are ongoing and in the future applications could be submitted to the Food and Drug Administration (FDA) to equip the country’s arsenal against COVID-19. Both vaccines are also being reviewed by the World Health Organization.
|Dosage||2 doses, 28 days apart||2 doses, 21 days apart|
|Storage||standard refrigeration||standard refrigeration|
|Type||chimpanzee adenovirus||inactivated virus|
|Approval status||U.S. and international clinical trials||Various international clinical trials|
|U.S. availability||300 million doses owned, but not approved for use||none|
AstraZeneca vs. Sinovac Efficiency
Both AstraZeneca and Sinovac vaccines are still undergoing clinical trials around the world, so there is some uncertainty as to how effective each vaccine is against COVID-19
There was some debate about the effectiveness of the AstraZeneca vaccine in late 2020, as it turned out that some people in the first study group received only half the dose of the vaccine.
While AstraZeneca claimed that the vaccine was 70 percent effective, it later reported that it was 62 percent effective in people given two full doses and almost 90 percent in those given half and one full dose. AstraZeneca uses these two percent for an average of 76 percent efficiency.
Data on Sinovac CoronaVac are limited as a number of international vaccine studies are still ongoing. In a report, researchers reported that between 97 and 100 percent of the people vaccinated in clinical trials developed antibodies to COVID-19, but not all immune response markers measured in the other studies were tested with CoronaVac.
Another report on the efficacy of CoronaVac shows that the results of a Phase 3 clinical trial have not yet been published by Sinovac, but a Chilean study showed an efficacy rate of only 56.5 percent after full vaccination with CoronaVac.
AstraZeneca vs. Sinovac side effects
Many of the side effects of vaccines currently available for COVID-19 are similar, with pain and sensitivity at the injection site leading to the most common reaction.
In the case of CoronaVac, pain at the injection site was the most common side effect, with 17 to 21% of people receiving different doses of the vaccine.
In most cases, the reaction is mild and resolves within 2 days. In the phase 1 vaccine study, there was a case in which the beneficiaries developed an allergic skin reaction with scars, but were treated with antihistamines and steroids and recovered within 3 days.
Systemic reactions that are not limited to the injection site include:
- muscle weakness
Experimental data show that these symptoms are much smaller than the pain at the injection site.
Reaction on people of color.
Redness, irritation and itching can be easily triggered in areas of redness and swelling of the white, but it can be more difficult to detect hives or rashes on other skin tones.
If you have black or brown skin, it may be difficult to see redness, but you may recognize itching and skin irritation:
- swollen knot
If you have swelling in your mouth or throat or difficulty breathing, this is a sign of an anaphylactic allergic reaction. Call 911 or go to the nearest emergency department immediately.
AstraZeneca attracts more attention due to the side effects of the vaccine, as some people develop blood clots after vaccination.
Vaccination has been delayed in many parts of the world, as regulators have monitored blood clotting and concluded it is a very rare side effect – affecting about 86 people in 25 million who have been vaccinated. European regulators allow AstraZeneca to continue the vaccination program, but some countries limit its use to older adults.
Other side effects of AstraZeneca that are also rare include:
- inflammation around the spinal cord
- hemolytic anemia
- high fever
All these symptoms disappeared without further problems. The most common side effects are:
- pain at the injection site
- slight tenderness
- muscle pain
Most of these reactions were mild according to the experimental data.
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